Case presentation: 67-year-old patient, with poor therapeutic adherence, is offered to be part of the SPD service; service that becomes the gateway for another care service of the community pharmacy, pharmacotherapeutic care. Study and evaluation of the case: The evaluation of the initial state of health shows that some of the health problems could be related to an RNM to the medication. Failures of ineffectiveness to antihypertensive treatment and safety to antipsychotic treatment are detected. Intervention: referred to the primary care team with a report of the results of the pharmacotherapeutic follow-up service and a proposal to modify the pharmacotherapy. Results: Regarding arterial hypertension, a third active principle was added for its control, which presented an adverse reaction and therefore required a substitution of said treatment. On the other hand, the negative results associated with antipsychotic treatment were confirmed and a gradual deprescription began. Conclusions: Coordination between the different health professionals was essential. The community pharmacist detected DRP and NOM that negatively affect the quality of life of polymedicated patients.