Farm Comunitarios. 2024 Jul 15;16(3):24-28. doi: 10.33620/FC.2173-9218.(2024).17

Systematic review on the efficacy and safety of cytisine against nicotine dependence

González Pérez L1, Núñez Velasco M1, Moreno López C2
1. Family and Community Medicine Resident. Zaragoza Sector I 2. Family and Community Doctor. Actur West Health Center. Zaragoza
González L, Núñez M, Moreno C. Systematic review on the efficacy and safety of cytisine against nicotine dependence. Farm Comunitarios. 2024 Jul 15;16(3):24-28. doi: 10.33620/FC.2173-9218.(2024).17
Abstract : 

Introduction: tobacco is one of the main causes of preventable mortality in our environment, in addition to having been correlated with numerous diseases. Smoking cessation improves health status and life expectancy. Pharmacological treatment of smoking cessation increases the likelihood that patient will successfully quit smoking.

Method and design: a search was carried out in the PubMed and UpToDate databases, obtaining a total of 11 systematic reviews or meta-analyses published in the last five years. After applying inclusion criteria and reading summaries, 5 total articles were obtained for the final review.

Results and discussion: Cytisine is a safe and effective treatment for smoking cessation. The most effective treatment in the clinical trials reviewed is varenicline associated with nicotine replacement therapy.

There is less evidence collected on cytisine treatment, but it shows that it is also an effective therapy in smoking cessation, also demonstrating its usefulness in the long term. In addition, therapy with cytisine seems to entail fewer adverse effects than treatment with varenicline.

Editor: © SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. 
Copyright© SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. This article is available from url https://www.farmaceuticoscomunitarios.org/. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en

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