Monitored Dosage System: the path to the safety and efficacy of medication

The MDS service, from the community pharmacy, is an essential tool to improve adherence and achieve the safety and efficacy of treatments in chronic patients.

In this case a patient of the pharmacy asked for help in order to organize his therapy and after informing him of the MDS we offered and signing his informed consent, all the information required about his medication and health problems was required following Guía práctica para los Servicios Profesionales Farmacéuticos Asistenciales en la Farmacia Comunitaria (Foro AF-FC) methology. Drugs metabolic and transporter enzymes were included.

Once the medication was studied, different adverse drug reaction due to lack of efficacy and safety were detected. Once all his ADRs have been evaluated, and if they are real or potential, with the aim to decreasing liver enzymes the interaccion between Pravastatin and Fenofibrate was intervened. The interaction between fentanyl and buprenorphine were also reported as a cause of his anxiety episodes.

After the intervention, fenofibrate and pravastatin were withdrawn and the GAMMA GT values ​​returned to the optimal range while the controlled cholesterol concentration was maintained at a suitable range. Currently, the patient collects his medication weekly from the pharmacy and he is monitored, in case any symptoms appear due to further possible drug interactions.