Farm Comunitarios. 2018 Dec 28;10(4):29-32. doi: 10.5672/FC.2173-9218.(2018/Vol10).004.06

Do we know all the pharmacological interactions ? The OATP1B1 transporter

Martínez Celdran LM1, Guevara Ferrando J1, Moreno Royo L2
1. Alumno 5º curso farmacia en la Universidad Cardenal Herrera – CEU. Alfara del Patriarca. Valencia. 2. Catedrática de farmacología y Vicedecana en la Facultad de Ciencias de la Salud. Universidad Cardenal Herrera – CEU. Alfara del Patriarca. Valencia.
Martínez LM, Guevara J, Moreno L. Do we know all the pharmacological interactions ? The OATP1B1 transporter. Farm Comunitarios. 2018 Dec 28;10(4):29-32. doi: 10.5672/FC.2173-9218.(2018/Vol10).004.06
Abstract : 

In the elderly, polymedication is frequent. This increases the risk of adverse reactions to medications, and also the risk of interactions that may be relevant. The most frequent interactions are those that affect the pharmacokinetics of drugs and, especially, their metabolism. Here the cytochrome P450 has a lot of relevance, but for a little more than a decade we know another mechanism involved, the membrane transporter proteins. Within these are the OATP (Organic anion transporting polypeptide) of which there are different types and locations. The competition of different substrates for these proteins can generate interactions that end up having an impact on the pharmacotherapeutic treatment of the patient.

Editor: © SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. 
Copyright© SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. This article is available from url https://www.farmaceuticoscomunitarios.org/. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en

Share

-

Related contents

Manual for authors

Journal Information